Cleopatra IV reigned as queen of Egypt briefly from 116-115 BC, jointly with her husband Ptolemy IX Lathyros. She later became queen consort of Syria.

She married Lathyros, her brother, in 116 BC, and thus became joint ruler of Egypt. However, her high position only lasted a few months, for their mother and co-ruler Cleopatra III pushed her out and replaced her with Cleopatra Selene.

Very upset with her mother, Cleopatra fled Egypt and went to Cyprus, where she raised an army and attempted to marry her other brother, Ptolemy X Alexander. However, Alexander wouldn't marry her, so she went to Syria, where Antiochus IX Cyzicenus accepted her large army as a dowry and married her.

Ptolemaic Queen of Egypt with Ptolemy IX and Cleopatra III
Preceded by: Ptolemy IX and Cleopatra III
Succeeded by: Ptolemy IX and Cleopatra III