Cleopatra Selene was queen consort to Ptolemy IX Lathyros of Egypt.

She was the daughter of Ptolemy VIII of Egypt and Cleopatra III of Egypt. She was married to Lathyros after her sister Cleopatra IV was pushed out by her mother. She was not made co-ruler, unlike the many sister-wives of Ptolemaic kings. She bore Lathyros Berenice III.

She may have also wed Ptolemy X Alexander I later, possibly bearing him Ptolemy XI Alexander II.