Sir David William Cross MacMillan FRS FRSE (born 16 March 1968[2][unreliable source?]) is a Scottish[1][3][4][5][6][7] chemist and the James S. McDonnell Distinguished University Professor of Chemistry at Princeton University, where he was also the chair of the Department of Chemistry from 2010 to 2015.[8][9] He shared the 2021 Nobel Prize in Chemistry with Benjamin List "for the development of asymmetric organocatalysis".[10] MacMillan used his share of the $1.14 million prize to establish the May and Billy MacMillan Foundation.[11]
Education and early life
MacMillan was born in Bellshill, North Lanarkshire, Scotland, in 1968 and grew up in nearby New Stevenston.[12] He attended the local state-funded schools, New Stevenston Primary and Bellshill Academy, and credited his Scottish education and Scottish upbringing for his success.[13][12]
He received his undergraduate degree in chemistry at the University of Glasgow, where he worked with Ernie Colvin.[14][15]
In 1990, he left the UK to begin his doctoral studies under the direction of Professor Larry Overman at the University of California, Irvine. During this time, he focused on the development of new reaction methodology directed toward the stereocontrolled formation of bicyclic tetrahydrofurans. MacMillan's graduate studies culminated in the total synthesis of 7-(−)-deacetoxyalcyonin acetate, a eunicellin diterpenoid isolated from the soft coral Eunicella stricta.[16] He earned his Ph.D. in 1996.[15]
Career and research
Upon receiving his PhD., MacMillan accepted a position with Professor David Evans at Harvard University. His postdoctoral studies centered on enantioselective catalysis, in particular, the design and development of Sn(II)-derived bisoxazoline complexes (Sn(II)box).[15]
MacMillan began his independent research career as a member of the chemistry faculty at the University of California, Berkeley in July 1998. He joined the department of chemistry at Caltech in June 2000, where his group's research interests centered on new approaches to enantioselective catalysis. In 2004, he was appointed as the Earle C. Anthony Professor of Chemistry. He became the James S. McDonnell Distinguished University Professor at Princeton University in September 2006.[15]
First generation MacMillan catalyst
He is considered to be one of the founders of organocatalysis.[17] In 2000, MacMillan designed small organic molecules that can provide or accept electrons and therefore efficiently catalyse reactions.[17][18] He developed catalysts that can drive asymmetric catalysis, in which a reaction produces more of the left-handed version of a molecule than the right-handed one (chirality), or vice versa.[17] MacMillan's research group has made many advances in the field of asymmetric organocatalysis, and they have applied these new methods to the synthesis of a range of complex natural products.[15][17] He developed chiral imidazolidinone catalysts.[19][18][20] MacMillan catalysts [de] are used in various asymmetric syntheses. Examples include Diels-Alder reactions,[18] 1,3-dipolar cycloadditions,[21] Friedel-Crafts alkylations[22] or Michael additions.[20]
MacMillan has also extensively developed photoredox catalysis for use in organic synthesis.[23][24][25]
Between 2010 and 2014, MacMillan was the founding editor-in-chief of the journal Chemical Science, the flagship general chemistry journal published by the Royal Society of Chemistry.[15]
As of 2021, MacMillan has an h-index of 110 according to Google Scholar[26] and of 100 according to Scopus.[27]
Honours and awards
MacMillan was knighted in the 2022 Birthday Honours for services to chemistry and science.[28][29]
2002 Sloan Research Fellowship[30]
2004 Corday-Morgan medal of Royal Institute of Chemistry[31]
2012 Elected a Fellow of the Royal Society (FRS)[32][33]
2012 Elected as a member of the American Academy of Arts and Sciences[34]
2013 Elected a Corresponding Fellow of the Royal Society of Edinburgh (FRSE)[35]
2015 Harrison Howe Award[36]
2017 Ryoji Noyori Prize[37]
2018 Elected a member of the National Academy of Sciences[15]
2021 Nobel Prize in Chemistry[10]
List
List of Nobel laureates affiliated with Princeton University
List of Nobel laureates
References
"Princeton's David MacMillan receives Nobel Prize in chemistry". Princeton University. 6 October 2021. Retrieved 7 October 2021.
"Professor David MacMillan FRS". Retrieved 15 October 2021.
"David MacMillan: 'Being Scottish helped me win Nobel Prize'". BBC News. 7 October 2021. Retrieved 15 October 2021.
Paterson, Laura (6 October 2021). "Scottish scientist jointly wins Nobel Prize in chemistry". www.standard.co.uk. Retrieved 8 October 2021.
"Chemistry Nobel awarded for mirror-image molecules". BBC News. 6 October 2021. Retrieved 8 October 2021.
Russell, Jennifer (6 October 2021). "Scots scientist wins Nobel Prize for chemistry". Daily Record. Retrieved 8 October 2021.
"Scottish scientist jointly wins Nobel Prize in chemistry". uk.news.yahoo.com. Retrieved 8 October 2021.
"The MacMillan Group". Macmillan Group. Retrieved 15 June 2020.
"David MacMillan". American Chemical Society Division of Organic Chemistry. 15 December 2016. Retrieved 12 July 2022.
"The Nobel Prize in Chemistry 2021". NobelPrize.org. Retrieved 6 October 2021.
Service, Purdue News. "David MacMillan, the 2021 Nobel laureate in chemistry, to join President Chiang for Presidential Lecture Series on Feb. 13". www.purdue.edu. Retrieved 16 August 2023.
"David MacMillan: 'Being Scottish helped me win Nobel Prize'". BBC News. 7 October 2021. Retrieved 7 October 2021.
"Success wouldn't have happened if I wasn't Scottish, says Bellshill-born Nobel Prize winner". HeraldScotland. Retrieved 9 November 2021.
"Bellshill man and former Glasgow University student David WC MacMillan wins the Nobel prize for chemistry". Glasgow Times. Retrieved 7 October 2021.
"David MacMillan". National Academy of Sciences. Retrieved 7 October 2021.
MacMillan, David William Cross (1996). Stereocontrolled formation of bicyclic tetrahydrofurans ; and, Enantioselective total synthesis of eunicellin diterpenes (Ph.D. thesis). University of California, Irvine. OCLC 35966904. ProQuest 304225710.
Castelvecchi, Davide; Stoye, Emma (6 October 2021). "'Elegant' catalysts that tell left from right scoop chemistry Nobel". Nature. Springer Science and Business Media LLC. 598 (7880): 247–248. Bibcode:2021Natur.598..247C. doi:10.1038/d41586-021-02704-2. ISSN 0028-0836. PMID 34616090. S2CID 238422185.
Ahrendt, Kateri A.; Borths, Christopher J.; MacMillan, David W. C. (15 April 2000). "New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels−Alder Reaction". Journal of the American Chemical Society. American Chemical Society (ACS). 122 (17): 4243–4244. doi:10.1021/ja000092s. ISSN 0002-7863.
"David MacMillan". Princeton University Department of Chemistry. 21 July 2014. Retrieved 7 October 2021.
Paras, Nick A.; MacMillan, David W. C. (12 June 2002). "The Enantioselective Organocatalytic 1,4-Addition of Electron-Rich Benzenes to α,β-Unsaturated Aldehydes". Journal of the American Chemical Society. American Chemical Society (ACS). 124 (27): 7894–7895. doi:10.1021/ja025981p. ISSN 0002-7863. PMID 12095321.
Jen, Wendy S.; Wiener, John J. M.; MacMillan, David W. C. (26 September 2000). "New Strategies for Organic Catalysis: The First Enantioselective Organocatalytic 1,3-Dipolar Cycloaddition". Journal of the American Chemical Society. American Chemical Society (ACS). 122 (40): 9874–9875. doi:10.1021/ja005517p. ISSN 0002-7863.
Paras, Nick A.; MacMillan, David W. C. (13 April 2001). "New Strategies in Organic Catalysis: The First Enantioselective Organocatalytic Friedel−Crafts Alkylation". Journal of the American Chemical Society. American Chemical Society (ACS). 123 (18): 4370–4371. doi:10.1021/ja015717g. ISSN 0002-7863. PMID 11457218.
Prier, Christopher K.; Rankic, Danica A.; MacMillan, David W. C. (19 March 2013). "Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis". Chemical Reviews. 113 (7): 5322–5363. doi:10.1021/cr300503r. ISSN 0009-2665. PMC 4028850. PMID 23509883.
Shaw, Megan H.; Twilton, Jack; MacMillan, David W. C. (19 August 2016). "Photoredox Catalysis in Organic Chemistry". The Journal of Organic Chemistry. 81 (16): 6898–6926. doi:10.1021/acs.joc.6b01449. ISSN 0022-3263. PMC 4994065. PMID 27477076.
Nicewicz, David A.; MacMillan, David W. C. (3 October 2008). "Merging Photoredox Catalysis with Organocatalysis: The Direct Asymmetric Alkylation of Aldehydes". Science. 322 (5898): 77–80. Bibcode:2008Sci...322...77N. doi:10.1126/science.1161976. PMC 2723798. PMID 18772399.
David MacMillan publications indexed by Google Scholar Edit this at Wikidata
David MacMillan publications indexed by the Scopus bibliographic database. (subscription required)
"No. 63714". The London Gazette (Supplement). 1 June 2022. p. B2.
Newsroom, The (8 June 2022). "Nobel prize winning chemist from Bellshill has now been knighted by the Queen". GlasgowWorld. Retrieved 9 June 2022.
"MacMillan Awarded Sloan Research Fellowship". California Institute of Technology. August 2002. Retrieved 6 October 2021.
"Caltech Faculty Awards and Honors 2004–2005" (PDF). California Institute of Technology. Archived from the original (PDF) on 11 August 2011. Retrieved 20 June 2012.
"New Fellows 2012". Royal Society. Retrieved 20 June 2012.
"Sir David MacMillan's Royal Society Fellowship Biography". The Royal Society. Retrieved 18 June 2022.
"David W.C. MacMillan". American Academy of Arts & Sciences. Retrieved 15 June 2020.
"Professor David William Cross MacMillan FRS, CorrFRSE – The Royal Society of Edinburgh". The Royal Society of Edinburgh. Retrieved 1 February 2018.
"Past Recipients of the Harrison Howe Award". Retrieved 7 October 2021.
"The Society of SynthRyoji Noyori Prize Recipients". www.ssocj.jp (in Japanese). Society of Synthetic Organic Chemistry, Japan. Archived from the original on 22 October 2017. Retrieved 2 November 2017.
External links
Scholia has a profile for David MacMillan (Q5237001).
David MacMillan on Nobelprize.org Edit this at Wikidata
vte
Laureates of the Nobel Prize in Chemistry
1901–1925
1901: Jacobus van 't Hoff 1902: Emil Fischer 1903: Svante Arrhenius 1904: William Ramsay 1905: Adolf von Baeyer 1906: Henri Moissan 1907: Eduard Buchner 1908: Ernest Rutherford 1909: Wilhelm Ostwald 1910: Otto Wallach 1911: Marie Curie 1912: Victor Grignard / Paul Sabatier 1913: Alfred Werner 1914: Theodore Richards 1915: Richard Willstätter 1916 1917 1918: Fritz Haber 1919 1920: Walther Nernst 1921: Frederick Soddy 1922: Francis Aston 1923: Fritz Pregl 1924 1925: Richard Zsigmondy
1926–1950
1926: Theodor Svedberg 1927: Heinrich Wieland 1928: Adolf Windaus 1929: Arthur Harden / Hans von Euler-Chelpin 1930: Hans Fischer 1931: Carl Bosch / Friedrich Bergius 1932: Irving Langmuir 1933 1934: Harold Urey 1935: Frédéric Joliot-Curie / Irène Joliot-Curie 1936: Peter Debye 1937: Norman Haworth / Paul Karrer 1938: Richard Kuhn 1939: Adolf Butenandt / Leopold Ružička 1940 1941 1942 1943: George de Hevesy 1944: Otto Hahn 1945: Artturi Virtanen 1946: James B. Sumner / John Northrop / Wendell Meredith Stanley 1947: Robert Robinson 1948: Arne Tiselius 1949: William Giauque 1950: Otto Diels / Kurt Alder
1951–1975
1951: Edwin McMillan / Glenn T. Seaborg 1952: Archer Martin / Richard Synge 1953: Hermann Staudinger 1954: Linus Pauling 1955: Vincent du Vigneaud 1956: Cyril Hinshelwood / Nikolay Semyonov 1957: Alexander Todd 1958: Frederick Sanger 1959: Jaroslav Heyrovský 1960: Willard Libby 1961: Melvin Calvin 1962: Max Perutz / John Kendrew 1963: Karl Ziegler / Giulio Natta 1964: Dorothy Hodgkin 1965: Robert Woodward 1966: Robert S. Mulliken 1967: Manfred Eigen / Ronald Norrish / George Porter 1968: Lars Onsager 1969: Derek Barton / Odd Hassel 1970: Luis Federico Leloir 1971: Gerhard Herzberg 1972: Christian B. Anfinsen / Stanford Moore / William Stein 1973: Ernst Otto Fischer / Geoffrey Wilkinson 1974: Paul Flory 1975: John Cornforth / Vladimir Prelog
1976–2000
1976: William Lipscomb 1977: Ilya Prigogine 1978: Peter D. Mitchell 1979: Herbert C. Brown / Georg Wittig 1980: Paul Berg / Walter Gilbert / Frederick Sanger 1981: Kenichi Fukui / Roald Hoffmann 1982: Aaron Klug 1983: Henry Taube 1984: Robert Merrifield 1985: Herbert A. Hauptman / Jerome Karle 1986: Dudley R. Herschbach / Yuan T. Lee / John Polanyi 1987: Donald J. Cram / Jean-Marie Lehn / Charles J. Pedersen 1988: Johann Deisenhofer / Robert Huber / Hartmut Michel 1989: Sidney Altman / Thomas Cech 1990: Elias Corey 1991: Richard R. Ernst 1992: Rudolph A. Marcus 1993: Kary Mullis / Michael Smith 1994: George Olah 1995: Paul J. Crutzen / Mario Molina / F. Sherwood Rowland 1996: Robert Curl / Harold Kroto / Richard Smalley 1997: Paul D. Boyer / John E. Walker / Jens Christian Skou 1998: Walter Kohn / John Pople 1999: Ahmed Zewail 2000: Alan J. Heeger / Alan MacDiarmid / Hideki Shirakawa
2001–present
2001: William Knowles / Ryoji Noyori / K. Barry Sharpless 2002: John B. Fenn / Koichi Tanaka / Kurt Wüthrich 2003: Peter Agre / Roderick MacKinnon 2004: Aaron Ciechanover / Avram Hershko / Irwin Rose 2005: Robert H. Grubbs / Richard R. Schrock / Yves Chauvin 2006: Roger D. Kornberg 2007: Gerhard Ertl 2008: Osamu Shimomura / Martin Chalfie / Roger Y. Tsien 2009: Venkatraman Ramakrishnan / Thomas A. Steitz / Ada E. Yonath 2010: Richard F. Heck / Akira Suzuki / Ei-ichi Negishi 2011: Dan Shechtman 2012: Robert Lefkowitz / Brian Kobilka 2013: Martin Karplus / Michael Levitt / Arieh Warshel 2014: Eric Betzig / Stefan Hell / William E. Moerner 2015: Tomas Lindahl / Paul L. Modrich / Aziz Sancar 2016: Jean-Pierre Sauvage / Fraser Stoddart / Ben Feringa 2017: Jacques Dubochet / Joachim Frank / Richard Henderson 2018: Frances Arnold / Gregory Winter / George Smith 2019: John B. Goodenough / M. Stanley Whittingham / Akira Yoshino 2020: Emmanuelle Charpentier / Jennifer Doudna 2021: David MacMillan / Benjamin List 2022: Carolyn R. Bertozzi / Morten P. Meldal / Karl Barry Sharpless 2023: Moungi G. Bawendi / Louis E. Brus / Alexei I. Ekimov
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