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Actaplanin is a complex of broad-spectrum antibiotics made by Actinoplanes bacteria.[1][2] Research carried out by a group in Eli Lilly and Co. in 1984 identified several actaplanins using high-performance liquid chromatography.[3][4][5] Actaplanins A, B1, B2, B3, C1 and G were shown to be composed of the same peptide core, an amino sugar, and varying amounts of glucose, mannose, and rhamnose.[6]
Chemical structure of Actaplanin (*)
See also
Ristocetin (contains the same amino sugar as in actaplanin)
References
Debono, Manuel; Merkel, Kurt E.; Molloy, R. Michael; Barnhart, Mitchell; Presti, Eugene; Hunt, Ann H.; Hamill, Robert L. (1984). "Actaplanin, new glycopeptide antibiotics produced by Actinoplanes missouriensis. The isolation and preliminary chemical characterization of actaplanin". The Journal of Antibiotics. 37 (2): 85–95. doi:10.7164/antibiotics.37.85. PMID 6706856.
Huber, Floyd M.; Pieper, Richard L.; Tietz, Anthony J. (January 1987). "Characterization of the process for the biosynthesis of the actaplanin complex by Actinoplanes missouriensis". Journal of Fermentation Technology. 65 (1): 85–89. doi:10.1016/0385-6380(87)90069-0.
Debono, Manuel; Merkel, Kurt E.; Molloy, R. Michael; Barnhart, Mitchell; Presti, Eugene; Hunt, Ann H.; Hamill, Robert L. (1984). "Actaplanin, new glycopeptide antibiotics produced by Actinoplanes missouriensis. The isolation and preliminary chemical characterization of actaplanin". The Journal of Antibiotics. 37 (2): 85–95. doi:10.7164/antibiotics.37.85. PMID 6706856. Retrieved 25 December 2014.
US 4115552, Robert L Hamill & Donald C Delong, "Factor A and B of antibiotic A-4696", published 19 Sep 1978, assigned to Eli Lilly And Company
US 4322406, Manuel Debono; Robert E. Weeks & Herald J. Cole, "Antibiotic A-4696 factors B1, B2, B3, C1a, C3 and E1", published 30 Mar 1982, assigned to Eli Lilly And Company
Hunt, Ann H.; Elzey, Thomas K.; Merkel, Kurt E.; Debono, Manuel (February 1984). "Structures of the actaplanins". The Journal of Organic Chemistry. 49 (4): 641–645. doi:10.1021/jo00178a012.
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