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The Menke nitration is the nitration of electron rich aromatic compounds with cupric nitrate and acetic anhydride. The reaction introduces the nitro group predominantly in the ortho position to the activation group.[1] It may proceed via the intermediary of acetyl nitrate. The reaction is named after the Dutch chemist J.B. Menke.[2]
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See also
Zincke nitration
References
Wang Z (2009). "Menke Nitration". Comprehensive organic name reactions and reagents. Hoboken, N.J.: John Wiley. doi:10.1002/9780470638859.conrr425. ISBN 978-0-470-63885-9.
Menke JB (1925). "Nitration with nitrates". Recueil des Travaux Chimiques des Pays-Bas. 44: 141. doi:10.1002/recl.19250440209.
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