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Lycomedes, a Rhodian, was appointed to command the Persian garrison placed in Mytilene by Autophradates and the younger Pharnabazus, in B. C. 333. In the ensuing year the Persian garrisons were dislodged from the islands in the Aegaean by Alexander's officer, Hegelochus. (Arr. Anab. ii. 1, iii. 2; Curt. iv. 5.)
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